Then, the goal proteins or subdomains of them containing the target lysine may be produced recombinantly and the methylation also tested at protein degree. The horizontal axis represents the H3 sequence and lawyers the vertical axis represents the amino acids by which the corresponding row is mutated. A) Discrimination components of NSD1 for the recognition of amino acid residues on the positions subsequent to the target lysine (K36 in the experiment shown here).

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